Research Associate in Acute Lymphocytic Leukemia (ALL)

University of Manitoba

Research Associate in Acute Lymphocytic Leukemia (ALL)
Paul Albrechtsen Research Institute, CancerCare Manitoba,
Department of Pharmacology and Therapeutics
Rady Faculty of Health Sciences
University of Manitoba
Winnipeg, Manitoba, Canada
Position # 35471

The Haigh Lab at the Paul Albrechtsen Research Institute, CancerCare Manitoba and the University of Manitoba, Department of Pharmacology and Therapeutics is seeking a Research Associate with experience in the phenotypic and molecular characterization of B cell, and other hematological phenotypes associated with a 5-year CIHR funded project grant entitled “Role of ZEB2 in B cell Ontogeny and Transformation”. The CIHR is the leading federal funding agency for Biomedical Research in Canada.

The ideal candidate would have hands-on experience in:

1) Phenotypic analysis of hematological and ALL associated models including Flow Cytometry, Q-RT-PCR and methylcellulose assays, lentiviral transduction systems and xenotransplantation models.
2) Bulk/Single Cell RNA and ATACseq library preparation.
3) Working with bulk and single cell bioinformatics analysis including Cell Ranger, SCENIC and other advanced Python/R-based analysis platforms.
4) Development and use of CRISPRi/a-based genome editing technologies.

The salary range for this category is $50,000 - $71,025 per annum (40 hours/week), commensurate with qualifications and experience.

The successful candidate would have the opportunity to participate in numerous other research projects in helping to finish off manuscripts for publication and in further building a strong publication track record. As well, training and supervision of (under)graduate students is expected. Expert technical assistance in project planning/completion is available in the lab. In addition to competitive salary support and job security for 3 years, position may be extended based upon research outcomes and productivity. Relocation expenses may be reimbursed, in accordance with University Policy and Procedure.

Recent Selected Haigh Lab Publications:

JAK/BCL2 inhibition acts synergistically with LSD1 inhibitors to selectively target ETP-ALL Benyoucef A. et al., Leukemia 2022, Oct 13. 36:2802-2816

Interplay between the EMT transcription factor Zeb1 and Zeb2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity. Wang J. et al., PLOS Biology- 2021 19(9): e3001394

Reversible reprograming of cardiomyocytes to a fetal state drives adult heart regeneration in mice. Chen, Y. et al., Science-2021 Sept 24; 373(6562):1537-1540

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.
Carmichael C. et al., Blood. 2020 Aug 20;136(8):957-973

The City of Winnipeg (www.tourismwinnipeg.com), located where the Red and Assiniboine Rivers meet, is recognized for its vibrant, multicultural community and diverse culture. The city, with a growing population of more than 766,000, is home to internationally renowned festivals, galleries and museums, the historic Exchange District and The Forks, and ever-expanding research, education, and business sectors. From the Hudson Bay waters, across the farmland fields, to the pulse of the cities and towns, The Province of Manitoba’s (www.travelmanitoba.com) people and places – its 100,000 lakes, 92 provincial parks, winding river valleys and storied prairie skies – inspire. Winnipeg is still a reasonably priced city with a high standard and low cost of living compared with other major North American Cities.

The University of Manitoba is a driving force of innovation, discovery and advancement. Our momentum is propelled by our campus community – UM faculty, staff and students whose determination and curiosity shape our world for the better. Our teaching, learning and work environment is uniquely strengthened and enriched by Indigenous perspectives. With two main campuses in Winnipeg, satellite campuses throughout Manitoba, and world-wide research, UM’s impact is global.
The Paul Albrechtsen Research Institute offers state-of-the-art capabilities in molecular biology, proteomics, flow cytometry, single cell sequencing, live cell imaging, multimodal small animal imaging, and rodent genetic model creation. As well, as part of CancerCare Manitoba, there are ample opportunities work in a translational cancer research setting with a focus on helping to find new treatments for aggressive forms of Cancers.

The University of Manitoba and CancerCare Manitoba are committed to the principles of equity, diversity & inclusion and to promoting opportunities in hiring, promotion and tenure (where applicable) for systemically marginalized groups who have been excluded from full participation at the University and the larger community including Indigenous Peoples, women, racialized persons, persons with disabilities and those who identify as 2SLGBTQIA+ (Two Spirit, lesbian, gay, bisexual, trans, questioning, intersex, asexual and other diverse sexual identities). All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

The Rady Faculty of Health Sciences is committed to the social justice principles of equity, access & participation and to promoting opportunities in hiring, promotion and tenure (where applicable) for systemically marginalized groups who have been excluded from full participation at the University and the larger community including Indigenous Peoples, Black, racially marginalized communities, disabled persons and those who identify as 2SLGBTQIA+ (Two Spirit, lesbian, gay, bisexual, trans, questioning, intersex, asexual and other diverse sexual identities).

An inclusive, open and diverse community is essential to excellence and fosters voices that have been ignored or discouraged. To address the Rady Faculty of Health Sciences commitment to equity, access and participation, and in recognition of the underrepresentation of members of historically and currently excluded groups, we take proactive measures including implicit bias training for all hiring panels. We strive for diversity and cultural safety throughout the hiring process (hiring panels, short-list of candidates, interviews). The University acknowledges the potential impact that Career Interruptions and Personal Circumstances can have on an applicant's record of research achievement. Measures will be taken to ensure that these leaves will be taken into careful consideration during the evaluation process.

We encourage you to self-identity aspects of your identity that position you to bring currently under-represented viewpoints, expertise and forms of excellence to this role.
If you require accommodation supports during the recruitment process, please contact UM.Accommodation@umanitoba.ca or 204-474-7195. Please note this contact information is for accommodation reasons only.

Interested candidates should send their CV and statement of research interests directly to Professor Jody Jonathan Haigh at jody.haigh@umanitoba.ca. Interviews of qualified candidates will occur immediately and continue till the position is filled. Expected start date would be any time after April 3, 2025.

Application materials, including letters of reference, will be handled in accordance with the protection of privacy provision of The Freedom of Information and Protection of Privacy Act (Manitoba). Please note that curriculum vitae may be provided to participating members of the search process.